Resistance to thyrotropin
نویسندگان
چکیده
منابع مشابه
Two novel mutations in the thyrotropin (TSH) receptor gene in a child with resistance to TSH.
The TSH receptor is a G protein-coupled receptor that mediates the effects of TSH in thyroid development, growth, and synthetic function. We report here that a child with features of TSH resistance, including markedly increased serum TSH concentrations and low normal thyroid hormone levels, is a compound heterozygote for two novel mutations in the TSH receptor gene. One allele has a G to A tran...
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The thyrotropin receptor (TSHR) is a seven transmembrane G-protein linked glycoprotein expressed on the thyroid cell surface and which, under the regulation of TSH, controls the production and secretion of thyroid hormone from the thyroid gland. This membrane protein is also a major target antigen in the autoimmune thyroid diseases. In Graves' disease, autoantibodies to the TSHR (TSHR-Abs) stim...
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We have recently shown that the /3 subunit of thyrotropin (TSH) can be cross-linked to the TSH receptor [Buckland, Strickland, Pierce & Rees Smith (1985) Endocrinology (Baltimore) 116, 2122-2124; Buckland, Strickland & Rees Smith (1985) Biochem. Soc. Trans. 13, 942-943]. We failed, however, to cross-link the a subunit to the receptor; leaving the role of this subunit in the TSH-TSH-receptor int...
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ژورنال
عنوان ژورنال: Best Practice & Research Clinical Endocrinology & Metabolism
سال: 2017
ISSN: 1521-690X
DOI: 10.1016/j.beem.2017.03.004